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1981, circa February - Behringwerke AG (German blood product manufacturer)
A pasteurization procedure is developed and licensed in Germany by blood product manufacturer Behringwerke AG. It involves heating factor concentrates at 60°C for ten hours. An article demonstrating the efficacy of the pasteurization process is published the same year.

Note: Other manufacturers are reluctant to adopt this technique over concerns regarding:

  • 50-90% loss of yield,
  • factor supply could be in jeopardy
  • pasteurized factor will cost ten times more
  • concerns over the effectiveness of inactivating non-A non-B hepatitis
  • patients might develop inhibitors.
Source: Krever Commission Report (1997), Vol 3, Part IV, Chap. 27, page 754.
Additional Source: NEJM, Vol 316, No 15 pps 918 – 922.
Type: Pasteurisation procedure licensed
Location: Germany / USA
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1984, January - Cutter - License / Pasteurization Process
Cutter receives US license to distribute factor concentrates subjected to a liquid pasteurisation process involving heating at 60°C for ten hours.
Source: Krever Commission Report (1997), Vol 3, Part IV, Chap. 27, page 755.
Type: US License Pasteurization
Location: USA
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1984, April - Bayer - Secures Patent for Pasteurisation Process
Bayer publishes a patented method for the pasteurization of Factor VIII.
Source: Hepatitis C and Heat Treatment Of Blood Products For Haemophiliacs In The Mid 1980s. Scottish Executive – Health Department. October 2000, Annex A, Page 3.
http://www.scotland.gov.uk/library3/health/hepatitis_c.pdf
Type: Patent Publishing
Location: USA
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1987, 23 March - Miss Cunningham / BTSB - HT3
It is now known (in 1987) that dry heating is ineffective in preventing Non-A Non-B Hepatitis. In a scientific meeting, Miss Cunningham, discusses various methods of heat treatment, and notes that the British protocol of pasteurisation of 80° Centigrade for 72 hours is effective against transmission of Non-A, Non-B Hepatitis and AIDS.
Source: Lindsay Tribunal: Page 56
http://www.digitalop.com/ihs/ole/images/Lindsay_Tribunal.doc
Type: Scientific Meeting
Location: UK
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