The taintedblood Timeline  -  what really happened...

A number of articles in the New England Journal of Medicine on Hemophiliacs and AIDS:

• Lederman reports widespread immunity abnormalities, possibly linked to AIDS.
• Menitove states that AIDS has a 40 per cent mortality, and reports widespread cell abnormalities.
• Desforges recommends Cryoprecipitate rather than concentrate because of the risk of AIDS.

First UK haemophiliac dies of AIDS from US Factor VIII administered in December 1981.

In the notes of the 14th Meeting of the UK Haemophilia Centre Directors on 17th October 1983, it is clear that the Directors have early knowledge of the risk of AIDS to spouses of haemophiliac patients:

Under the heading "AIDS UK Situation" the following is stated:

"Spouses of patients who received FVIII will also be followed. Choice of control group for the above study not decided as yet but is considered critical to the study." (Page 1, circa line 21)

On page 4, under the heading "U.K. Situation", the minutes state:

"Twenty-two patients have N.I.H diagnostic criteria for AIDS - many through contact in USA. 10 patients have so far died. Details of haemophiliac cases (A1 and A4) are contained in Appendix B and the follow-up protocol is to be circulated in due course."

The following comment, made during the AIDS crisis also doesn't bode well:

"...Neither Dr Boulton, Dr Ludlam or myself considered it appropriate to discuss publicly the details of our current 'clinical trial' on heat treated FVIII" (Page 1)

Note: Rather than focussing on control groups and studies, it would have been prudent and more ethically sound to commence an immediate notification exercise with the imparting of advice to the spouses of patients with haemophilia.

A summary is published in the US of 18 cases of AIDS, the only risk factors involved are the receipt of blood components in the 5 years before the onset of the illness.

The National Hemophilia Foundation learns that the CDC has received reports of 9 new cases of AIDS among US hemophiliacs in the first quarter of 1984. The National Hemophilia Foundation again fails to recommend any change in treatment.

In a Haemophilia Society 'Haemofact' leaflet, May 1984 Release No. 3, Christine A. Lee, Senior Registrar at the Royal Free Haemophilia Centre, comments rather too conservatively on the occurrence of AIDS in UK haemophiliacs:

"The occurrence of acquired immunodeficiency syndrome (AIDS) in haemophiliac patients has strongly suggested transmission of the disorder by blood products and epidemiological studies have suggested it may be related to a transmissible agent."

"In Great Britain the number of haemophiliacs who have been reported with AIDS remain at 2. Thus the incidence is less than 1 in 1,000 patients at risk."

Note: We are concerned to read that the incidence of AIDS in haemophiliacs was only described at 0.1%. Surely this was a gross misrepresentation of the risk from blood products? Christine A. Lee's comments on the risk suggests a misleading mindset as she seemed to think the total haemophilia community totalled 2,000. This could not possibly have been right - it should've been nearer 5,000. We have to wonder what statistical information this population figure was based on?

Background: The following list of developments detail what we believe Christine A. Lee should have considered before making the statement; (after all, the clues were there as to the real scale of the risk):

• In January 1983, Desforges published an article in the NEJM on Hemophiliacs and AIDS, recommending that cryoprecipitate rather than concentrate be used.
• In August 1983, the first UK haemophiliac dies of AIDS from US Factor VIII administered in December 1981.
• Whilst in October 1983, in the UK, there were only 2 haemophiliac cases of AIDS, in the USA, however, there were 22 patients with N.I.H diagnostic criteria for AIDS and 10 patients had by that time died.
• In January 1984, a summary was published in the NEJM of 18 US cases of AIDS where blood components were involved.
• By April 1984, the National Hemophilia Foundation learned that the CDC had received reports of 9 new cases of AIDS among US haemophiliacs.

Note: We would like to point out that only 10 months later, (March 1985), the DHSS Finance Division (FA1), expresses fears that the haemophiliac population (around 5,000) could be very seriously affected indeed, with two-thirds possibly already sero-positive, and 240 haemophiliacs possibly manifesting AIDS within one year, and as many as 1,200 eventually developing AIDS.

In a DHSS Finance Division circular of 5 March 1985, we read of disturbing figures regarding the infections of UK haemophiliacs:

"If, however, your figures are right Britain's haemophiliac population, which I think is 5000, could be very seriously affected. You question whether the one-third sero-positive is accurate. The table below suggests what the implications of one-third sero-positive and two-thirds sero-positive would be:

	One-third sero-positive	Two-thirds sero-positive
Sero-positive	1,500	3,000
AIDS within one year	120	240
AIDS eventually	600	1,200

Frightening figures.

The Finance Division circular goes on to make the following utterly monstrous comment:

"Of course the maintenance of the life of a haemophiliac is itself EXPENSIVE, and I am very much afraid that those who are already doomed will generate SAVINGS which more than cover the COST of testing blood donations. At this stage I do not want to have your minute or mine copied outside Finance Division." [Quoted verbatim. DHSS Finance Division: FA1. Dated 5th March 1985.]

Note: We find it hard to believe that the DHSS dared to commit such a disgraceful comment to paper. It is disgusting beyond belief that whilst haemophiliacs are dying, the first thing going through the minds of the FINANCIERS is the MONEY that will be saved by the deaths of these 'EXPENSIVE' haemophiliacs and that such SAVINGS can be spent on blood screening.

The DHSS Finance Division should be ashamed of themselves.